Description
Data Sheet
| Applications | Direct ELISA, Western Blot, Immuneprecipitation, immunohistochemistry. |
| Clone | NYRPLP. |
| Ig Subclass | mouse IgG1. |
| Immunogen | synthetic pPLP 139-151. |
| Protein Background | Lipophilin is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. PLP functions in myelination. plays a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations associated with PLP gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Two transcript variants encoding distinct isoforms have been identified for PLP gene.PLP is the major myelin protein from the central nervous system and plays an important role in the formation or maintenance of the multilamellar structure of myelin. |
| Purification Method | Ion exchange column. |
| Storage Procedures | In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |
| Synonyms | PLP, LIPOPHILIN, PMD, MMPL, SPG2, PLP/DM20. |
| Type | Mouse Antibody Monoclonal. |
