Description
Data Sheet
| Formulation | The erbb2 antibody is lyophilized in 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE. |
| Immunogen | The erbb2 antibody was raised in rabbits by immunization with the recombinant Human erbb2 (43.4 kDa, 397 a.a. and one extra AA, N-terminal Methionin) purified from E. coli. |
| Protein Background | HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2. |
| Stability | The lyophilized antibody remains stable and fully active until the expiry date when stored at 20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles and store frozen at 80°C. Reconstituted antibody can be stored at 4°C for a limited period of time; it does not show decline in activity after one week at 4°C. |
| Synonyms | NEU, NGL, HER2, TKR1, HER-2, c-erb B2, HER-2/neu, Receptor tyrosine-protein kinase erbB-2, EC 2.7.10.1, p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, CD340 antigen. |
| Type | Rabbit Anti Human Polyclonal |
