Description
Data Sheet
| Applications | ELISA. Inhibition Assays. Western Blotting. |
| Description | Catheprsin D Human Recombinant full length protein expressed in E.coli, shows a 48 kDa band on SDS-PAGE. The Catheprsin D is purified by proprietary chromatographic techniques. |
| Expression host | Escherichia Coli. |
| Formulation | Cathepsin D at 0.1mg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. |
| link | Purified by proprietary chromatographic technique. |
| Protein Background | Cathepsin D is synthesized as a 54kDa precursor, which is proteolytically processed to an intermediate 48kDa single chain, which matures into more stable 34kDa and 14kDa two chain form. It is an estrogen-regulated lysosomal protease that has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and xonnective tissue. Because of its mitogenic and proteolytic activities, it has been implicated as a prognostic marker in many tumor types. Cathepsin D is expressed in epithelial cells as well as in macrophages. |
| Reagent Appearance | Sterile Filtered clear solution. |
| Stability | Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles. |
| Synonyms | Cathepsin D, EC 3.4.23.5, CTSD, CPSD, CLN10, MGC2311. |
