Description
Data Sheet
| Clone | RYNmCTLA-4. |
| Ig Subclass | Hamster IgG. |
| Immunogen | mixture of mouse activated T cells. |
| Protein Background | CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. |
| Purification Method | Ion exchange column. |
| Storage Procedures | Lyophilized: store at 4oC. After reconstitution, if not intended for use within a month, aliquot and store at -20oC. |
| Synonyms | GSE, CD152, IDDM12, CELIAC3, CTLA-4. |
| Type | Hamster Anti Mouse Monoclonal. |
