Description
Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the influenza A virus which can cause illness in humans and many other animal species. H5N1 is a highly pathogenic avian (bird) flu virus that has caused serious outbreaks in domestic poultry in parts of Asia and the Middle East. Highly pathogenic refers to the virus’s ability to produce disease.. Like all other influenza A subtypes, the H5N1 subtype is an RNA virus. It has a segmented genome of eight negative sense, single-strands of RNA, abbreviated as PB2, PB1, PA, HA, NP, NA, MP and NS. HA codes for hemagglutinin, an antigenic glycoprotein found on the surface of the influenza viruses and is responsible for binding the virus to the cell that is being infected. Hemagglutinin plays a major role in the determination of host range restriction and virulence because human influenza HA preferentially binds to SA-α-2,6 while avian influenza HA preferentially binds to SA-α-2,3.
John Buozis, Syed Rahin Ahmed, Rohit Chand, Éva Nagy, Suresh Neethirajan
bioRxiv 343376; doi: https://doi.org/10.1101/343376
Data Sheet
| Application | For quantitative determination of hemagglutinin. |
| Assay principle | This assay is a sandwich Enzyme Linked-Immuno-Sorbent Assay (ELISA). |
| Assay Range | 125 – 8000 pg/ml |
| Expiration | Six months at 2 – 8 ⁰C. |
| Sample type | Serum, plasma, body fluids. |
| Sensitivity | 50 pg/ml |
| Size | 96T |
| Storage | Store at 2 – 8⁰C. Keep Standard and detection antibody at -20⁰C. |

