Description
Data Sheet
| Alternative Name of Analyte | MAPK8 |
| Assay duration | 4 hours |
| Assay format | Sandwich |
| Assay Range | 562-36000pg/ml |
| Background | c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock. They also play a role in T cell differentiation and the cellular apoptosis pathway. Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinases, MKK4 and MKK7 and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases.It has been suggested that this signaling pathway contributes to inflammatory responses in mammals and insects. |
| Sample type | serum, plasma, cell culture supernatant |
| Sensitivity | 54 pg/ml |
| Size | 96 Tests |
| Specificity | reactive with Human/Mouse/Rat Total JNK, reactivity with other related proteins not observed |
| Storage | 2-8℃ |
