Description
Data Sheet
| Alternative Name of Analyte | NTRK1；MTC；TRK；TRK1；TRKA；Trk-A；p140-TrkA |
| Assay duration | 4 hours |
| Assay format | Sandwich |
| Assay Range | 140-9000pg/ml |
| Background | High affinity nerve growth factor receptor also known as neurotrophic tyrosine kinase receptor type 1 or TRK1-transforming tyrosine kinase protein or Trk-A is a protein that in humans is encoded by the NTRK1 gene.This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself (autophosphorylation) and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. |
| Sample type | serum, plasma, cell culture supernatant |
| Sensitivity | 13.5 pg/ml |
| Size | 96 Tests |
| Specificity | reactive with Human Total TrkA, reactivity with other related proteins not observed |
| Storage | 2-8℃ |
