Description
Background
Arresten , also known as COL4A1 (Collagen type IV, alpha-1). Type IV procollagen contains 2 distinct chains. The collagen IV molecule is a heterotrimer of 2 alpha-1 chains and 1 alpha-2 chain .The COL4A1 gene is mapped to chromosome 13 and it is expressed in human donor corneas. Human arresten binds to alpha-1/beta-1 integrin and inhibits migration, proliferation, and tube formation by endothelial cells. Arresten elicited significant antiangiogenic effects and tumor growth inhibition in vitro but failed to do the same in alpha-1 integrin knockout mice.
Data Sheet
| Form | lyophilized |
| Ig type | rabbit IgG |
| Immunogen/Antigen | A synthetic peptide corresponding to a sequence at the C-terminal |
| Reconstitution | 0.2ml of distilled water will yield a concentration of 500μg/ml. |
| Size | 100ug/vial |
| Storage | At -20C for one year. After reconstitution, at 4C for one month. |
