Human C1s Proenzyme

Background:

C1s proenzyme is the native form of C1s enzyme and is a subunit of the C1 complex. C1s proenzyme is an inactive zymogen until C1 is activated. C1 complex binds to and is activated by antigen-antibody complexes yielding C1r enzyme. C1r enzyme in the C1 complex activates C1s proenzyme generating C1s enzyme.

Storage:

-70℃ or below. Avoid freeze/thaw.

Source:

Normal human serum

Purity:

>90 % by SDS PAGE.

Molecular Weight:

Size:

86,000 Da (1 chain)

 250 µg/vial

Concentration:

1.0 mg/ml

Activity:

>80 % C1s binds 1:1 with excess C1-INH after activation

Buffer:

50 mM sodium phosphate, 130 mM NaCl, pH 7.2

Preservative:

None, 0.22 µm filtered.