Description
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Background: |
Native human C3 is a naturally glycosylated (approximately 2.7%) polypeptide containing two disulfide-linked chains. C3 is essential to the activation of all three pathways of complement activation. Initiation of each pathway generates proteolytic enzyme complexes (C3 convertases) which are bound to the target surface. These enzymes cleave a peptide bond in C3 releasing the anaphylatoxin C3a and activating C3b. |
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Storage: |
-70℃ or below. Avoid freeze/thaw. |
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Source: |
Normal human serum |
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Physical Appearance: |
Frozen liquid |
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Purity: |
>95% by SDS-PAGE |
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Molecular Weight: Size: |
185,000 Da (2 chains) 250 µg/vial |
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Concentration: |
1.0 mg/ml |
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Activity: |
>70% versus normal human serum standard |
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Buffer: |
10 mM sodium phosphate, 145 mM NaCl, pH 7.2 |
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Preservative: |
None, 0.22 µm filtered. |
