Description
Overview
Long Name
|
Antibody Type
|
Antibody Isotype
|
Host
|
Species Reactivity
|
Validated Applications
|
Purification
|
| CD59 molecule, complement regulatory protein |
Polyclonal |
IgG |
Rabbit |
Human |
IHC-P |
Immunogen affinity purified. |
Immunogen
|
| E.coli-derived human CD59 recombinant protein (Position: L26-N102). Human CD59 shares 47.1% amino acid (aa) sequence identity with rat CD59. |
Properties
Form
|
Lyophilized |
Size
|
100 µg/vial |
Contents
|
Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3. *carrier free antibody available upon request. |
Concentration
|
Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration). |
Storage
|
At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing. |
Additional Information Regarding the Antigen
Gene
|
CD59 |
Protein
|
CD59 glycoprotein |
Uniprot ID
|
P13987 |
Function
|
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. |
Tissue Specificity
|
|
Sub-cellular localization
|
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note: Soluble form found in a number of tissues. |
Sequence Similarities
|
Contains 1 UPAR/Ly6 domain. |
Aliases
|
16.3A5 antibody|1F5 antibody|1F5 antigen antibody|20 kDa homologous restriction factor antibody|CD 59 antibody|CD_antigen=CD59 antibody|CD59 antibody|CD59 antigen antibody|CD59 antigen complement regulatory protein antibody|CD59 antigen p18 20 antibody|CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) antibody|CD59 glycoprotein antibody|CD59 molecule antibody|CD59 molecule complement regulatory protein antibody|CD59_HUMAN antibody|Cd59a antibody|Complement regulatory protein antibody|EJ16 antibody|EJ30 antibody|EL32 antibody|FLJ38134 antibody|FLJ92039 antibody|G344 antibody| HRF 20 antibody|HRF-20 antibody|HRF20 antibody|Human leukocyte antigen MIC11 antibody|Ly 6 like protein antibody|Lymphocytic antigen CD59/MEM43 antibody|MAC inhibitory protein antibody|MAC IP antibody|MAC-inhibitory protein antibody|MAC-IP antibody|MACIF antibody|MACIP antibody|MEM43 antibody|MEM43 antigen antibody|Membrane attack complex (MAC) inhibition factor antibody|Membrane attack complex inhibition factor antibody|Membrane inhibitor of reactive lysis antibody|MGC2354 antibody|MIC11 antibody|MIN1 antibody|MIN2 antibody|MIN3 antibody|MIRL antibody|MSK21 antibody|p18 20 antibody|Protectin antibody|Surface antigen recognized by monoclonal antibody|16.3A5 antibody|T cell activating protein antibody |
Application Details
| Application |
Concentration* |
Species |
Validated Using** |
| Immunohistochemistry(Paraffin-embedded Section) |
0.5-1μg/ml |
Human |
AssaySolutio’s IHC/ICC Detection kit |
AssaySolution recommends Rabbit Peroxidase IHC/ICC Detection Kit (AKIT002B) for IHC(P). *Blocking peptide can be purchased at $65. Contact us for more information
Anti- CD59 antibody, ASA-B0391, IHC(P)
IHC(P): Human Tonsil Tissue
