Description
Overview
Long Name |
Antibody Type |
Antibody Isotype |
Host |
Species Reactivity |
Validated Applications |
Purification |
| bone morphogenetic protein receptor, type IB | Polyclonal | IgG | Rabbit | Human, Mouse, Rat | WB | Immunogen affinity purified. |
Immunogen |
||||||
| A synthetic peptide corresponding to a sequence in the middle region of human BMPR1B(145-160aa FCYFRYKRQETRPRYS), different from the related rat and mouse sequences by one amino acid. | ||||||
Properties
Form |
Lyophilized |
Size |
100 µg/vial |
Contents |
Antibody is lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3. *carrier free antibody available upon request. |
Concentration |
Reconstitute with 0.2 mL sterile dH2O (500 µg/ml final concentration). |
Storage |
At -20 °C for 12 months, as supplied. Store reconstituted antibody at 2-8 °C for one month. For long-term storage, aliquot and store at -20 °C. Avoid repeated freezing and thawing. |
Additional Information Regarding the Antigen
Gene |
BMPR1B |
Protein |
Bone morphogenetic protein receptor type-1B |
Uniprot ID |
O00238 |
Function |
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity). |
Tissue Specificity |
|
Sub-cellular localization |
Membrane; Single-pass type I membrane protein. |
Sequence Similarities |
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. |
Aliases |
Activin receptor like kinase 6 antibody|Acvrlk6 antibody|ALK 6 antibody|ALK6 antibody|alk6tr antibody|BMP type-1B receptor antibody|BMPR IB antibody|BMPR-1B antibody|Bmpr1b antibody|BMPRIB antibody|BMR1B_HUMAN antibody|Bone morphogenetic protein receptor type 1B antibody|Bone morphogenetic protein receptor type IB antibody|Bone morphogenetic protein receptor type-1B antibody|BR 1b antibody|BR1b antibody|CDw 293 antibody|CDw293 antibody|CDw293 antigen antibody|CFK 43a antibody|CFK43a antibody|Serine/threonine receptor kinase antibody|zALK 6 antibody|zALK6 antibody |
Application Details
| Application | Concentration* | Species | Validated Using** |
| Western blot | 0.1-0.5μg/ml | Human Mouse, Rat | AssaySolutio’s ECL kit |
AssaySolution recommends Rabbit Chemiluminescent WB Detection Kit (AKIT001B) for Western blot. *Blocking peptide can be purchased at $65. Contact us for more information
Anti-BMPR1B antibody, ASA-B0234, Western blotting
Recombinant Protein Detection Source: E.coli derived -recombinant Human BMPR1B, 49.0KD(162aa tag+D17-D289)
Lane 1: Recombinant Human BMPR1B Protein 10ng
Lane 2: Recombinant Human BMPR1B Protein 5ng
Lane 3: Recombinant Human BMPR1B Protein 2.5ng
Lane 4: Recombinant Human BMPR1B Protein 1.25ng
Recombinant Protein Detection Source: E.coli derived -recombinant Human BMPR1B, 49.0KD(162aa tag+D17-D289)
Lane 1: Recombinant Human BMPR1B Protein 10ng
Lane 2: Recombinant Human BMPR1B Protein 5ng
Lane 3: Recombinant Human BMPR1B Protein 2.5ng
Lane 4: Recombinant Human BMPR1B Protein 1.25ng
