Description
Related Products:
Human Pro-Collagen I alpha 1 ELISA Kit, PINP ELISA Kit, PIIINP ELISA Kit Human Pro-Collagen I alpha II ELISA kit Human Arresten/Collagen IV C-Cterminal domain ELISA
Data Sheet
| Alternate Names | COL4A3, collagen type IV alpha 3 chain, ATS2, ATS3 |
| Assay Range | 62.5 – 4000 pg/ml |
| Assay Type | Sandwich ELISA |
| Background | Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In Goodpasture’s syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. There are multiple alternate transcripts that appear to be unique to this human alpha 3 gene and alternate splicing is restricted to the six exons that encode this C-terminal domain. |
| Gene ID | 1282 |
| Sample Type | serum, plasma |
