Description
Data Sheet
| Antibody Properties | Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. |
| Available Conjugates | Staining, immunohistochemistry. For staining, use 10ul/1,000,000 cells. Titer for IH should be determined by the investigator. |
| Clone | hCD11b. |
| Ig Subclass | Mouse IgG1. |
| Immunogen | Purified human PBL Monocytes. |
| Immunological function | This antibody is also available unconjugated and conjugated to FITC. |
| Protein Background | Integrins are heterodimeric integral membrane proteins consisting of an ? chain and a ? chain. CD11b is an I-domain including ? integrin combines with the ? 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor also called MAC1. The ? M beta 2 integrin is crucial in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Purification Method | Ion exchange column. |
| Reconstitution | 1mg/ml in PBS (after reconstitution). |
| Storage Procedures | Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |
| Synonyms | Integrin alpha-M, Cell surface glycoprotein MAC-1 subunit alpha, CR-3 alpha chain, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11b antigen, ITGAM, CR3A, MO1A, CD11B, MAC-1, MAC1A, MGC117044. |
| Type | Mouse Anti Human Monoclonal. |
