Description
Human Growth Differentiation Factor 15 (Gdf15) ELISA Kit
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Data Sheet
| Alternate Names | GDF15; GDF-15; growth differentiation factor 15; MIC-1; PDF; PDFGDF-15; PLAB; PLABNRG-1; PTGF-beta; PTGFBPTGF-beta |
| Assay Range | 31.2 – 2000 pg/ml |
| Assay Time | 4.5 hours |
| Assay Type | Sandwich ELISA |
| Background | Growth/differentiation factor 15 (GDF15) was first identified as Macrophage inhibitory cytokine-1 or MIC-1.
It is a protein belonging to the transforming growth factor beta superfamily. Under normal conditions, GDF-15 is expressed in low concentrations in most organs and upregulated because of injury of organs such as such as liver, kidney, heart and lung. The function of GDF-15 is not fully cleared but it seems to have a role in regulating inflammatory pathways and to be involved in regulating apoptosis, cell repair and cell growth, which are biological processes observed in cardiovascular and neoplastic disorders. GDF-15 has shown to be a strong prognostic protein in patients with different diseases such as heart diseases and cancer. Metformin was shown to cause increased levels of GDF-15. This increase mediates the effect of body weight loss by metformin. |
| Dilution Factors | Undiluted for serum and plasma, 1 to 10 for urine. |
| Gene ID | 9518 |
| Kit Type | Colorimetric |
| Sample Type | Serum, plasma, urine |
| Sample Volume | 100 μL |
| Sensitivity | 15.3 pg/ml |
| Specificity | Native and recombinant human GDF-15 |
| Storage | 2 – 8 ℃ |
