Description
Background
PKBαalso knows as V-AKT murine thymoma vial oncogene homolog 1(ATK1). AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and is abrogated by mutations in the pleckstrin homology domain of AKT1. AKT1 gene is mapped to chromosome 14q32.3. Akt1/protein kinase B-alpha is critical for ischemic and VEGF-mediated angiogenesis. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
Data Sheet
| Application | Cross ReactivityHuman, mouse, rat, chicken. |
| Clone | IML-26 |
| Cross Reactivity | Human, mouse, rat, chicken. |
| Form | lyophilized |
| Ig type | mouse IgG1 |
| Immunogen/Antigen | Synthetic peptide corresponding to amino acids 461-477 |
| Reconstitution | 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, |
| Size | 100ug/vial |
| Storage | At -20C for one year. After reconstitution, at 4C for one |
