Description
Fms-related tyrosine kinase 4 (FLT-4), also known as VEGF-R3, is a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. Vascular endothelial growth factor receptor-3 (VEGFR-3) and its ligands, vascular endothelial growth factor-C (VEGF-C) and -D (VEGF-D), are the major molecules involved in developmental and pathological lymphangiogenesis. VEGFR3 antibodies specifically stain endothelial cells of lymphatic vessels and vessels around tumonrs such as lymphoma and in situ breast carcinoma.
Data Sheet
| Alternative Name of Analyte | PCL；FLT41；LMPH1A；VEGFR3 |
| Assay duration | 4 hours |
| Assay format | Sandwich |
| Assay Range | 62.5-4000 pg/ml |
| Background | This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. |
| Sample type | serum, plasma, cell culture supernatant |
| Sensitivity | 6 pg/ml |
| Size | 96 Tests |
| Specificity | reactive with Mouse sVEGF R3, reactivity with other related proteins not observed |
| Storage | 2-8℃ |
