Description
Data Sheet
| Applications | Western Blot, Immunoprecipitation. |
| Clone | PMYCSHG. |
| Description | Monoclonal antibodies are produced by immunizing mouse with synthetic peptide (EQKLISEEDL) coupled to KLH. |
| Formulation | 1PBS & 50% glycerol. |
| Ig Subclass | Mouse IgG1. |
| Protein Background | c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of c-Myc have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt’s lymphomas, suggesting its importance in the normal function of this gene. |
| Synonyms | MYC, CMYC, C-MYS, V-MYC, P64. |
| Type | Mouse Antibody Monoclonal. |
