Description
Data Sheet
| Applications | Direct ELISA, Western Blot, Immuneprecipitation. |
| Clone | NYRhVEGF. |
| Ig Subclass | Mouse IgM. |
| Immunogen | r.HumanVEGF. |
| Protein Background | Vascular endothelial growth factoris an important signaling proteininvolved in both vasculogenesisand angiogenesis. As its name implies, VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophagemigration, neurons, cancer cells, kidney epithelial cells ).VEGF mediates increased vascular permeability, induces angiogenesis, vasculogenesis and endothelial cell growth, promotes cell migration, and inhibits apoptosis. In vitro, VEGF has been shown to stimulate endothelial cell mitogenesisand cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor.Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. |
| Purification Method | Boric acid precipitation Protein concentration1mg/ml in PBS (after reconstitution). |
| References | 1.Title: Anti-vascular endothelial growth factor (VEGF) specific activity of intravenous immunoglobulin (IVIg).Publication: International immunology 21.9 (2009): 1057-1063Link: http://intimm.oxfordjournals.org/content/21/9/1057.full.pdf+html |
| Storage Procedures | In lyophilized form, for long periods, store at 4oC in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20oC. |
| Synonyms | Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, VEGF, MGC70609. |
| Type | Mouse Anti Human Monoclonal. |
